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J Vet Sci. 2006 Dec;7(4):355-359 |
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In vitro susceptibilities of Leptospira spp. and Borrelia burgdorferi isolates to amoxicillin, tilmicosin, and enrofloxacin
Doo Kim1,2, Dorsey Kordick3, Thomas Divers1, Yung-Fu Chang1,* |
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1College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. yc42@cornell.edu
2Department of Veterinary Medicine, Kangwon National University, Chunchon 200-701, Korea
3IDEXX Laboratories, Greensboro, NC 27410, USA |
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Antimicrobial susceptibility testing was conducted with
6 different spirochetal strains (4 strains of Leptospira spp.
and 2 strains of Borrelia burgdorferi) against 3 antimicrobial
agents, commonly used in equine and bovine practice. The
ranges of MIC and MBC of amoxicillin against Leptospira
spp. were 0.05-6.25 レg/ml and 6.25-25.0 レg/ml, respectively.
And the ranges of minimal inhibitory concentration
(MIC) and minimal bactericidal concentration (MBC) of
amoxicillin against B. burgdorferi were 0.05-0.39 レg/ml
and 0.20-0.78 レg/ml, respectively. The ranges of MIC and
MBC of enrofloxacin against Leptospira spp. were 0.05-
0.39 レg/ml and 0.05-0.39 レg/ml, respectively. Two strains
of B. burgdorferi were resistant to enrofloxacin at the highest
concentration tested for MBC (｜100 レg/ml). Therefore, the
potential role of tilmicosin in the treatment of leptospirosis
and borreliosis should be further evaluated in animal
models to understand whether the in vivo studies will
confirm in vitro results. All spirochetal isolates were
inhibited (MIC) and were killed (MBC) by tilmicosin at
concentrations below the limit of testing (‖0.01 レg/ml).
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