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J Vet Sci. 2007 Sep;8(3):299-301 |
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Identification of single-nucleotide polymorphisms of the prion protein gene in sika deer (Cervus nippon laiouanus)
Hyun-Jeong Jeong1, Joong-Bok Lee1, Seung-Yong Park1, Chang-Seon Song1, Bo-Sook Kim2, Jung-Rae Rho2, Mi-Hyun Yoo2, Byung-Hoon Jeong3, Yong-Sun Kim3, In-Soo Choi1,* |
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1Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea
2Animal Research Division, Seoul Grand Park Zoo, Gwacheon 427-420, Korea
3Ilsong Institute of Life Science, Hallym University, Anyang 431-060, Korea
* ischoi@konkuk.ac.kr |
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Polymorphisms of the prion protein gene (PRNP) have
been detected in several cervid species. In order to
confirm the genetic variations, this study examined the
DNA sequences of the PRNP obtained from 33 captive
sika deer (Cervus nippon laiouanus) in Korea. A total of
three single-nucleotide polymorphisms (SNPs) at codons
100, 136 and 226 in the PRNP of the sika deer were
identified. The polymorphic site located at codon 100 has
not been reported. The SNPs detected at codons 100 and
226 induced amino acid substitutions. The SNP at codon
136 was a silent mutation that does not induce any amino
acid change. The genotype and allele frequencies were
determined for each of the SNPs.
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