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J Vet Sci. 2008 Jun;9(2):203-205 |
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Aquaporin 1 expression in tissues of canines possessing inherited high K+ erythrocytes
Hideharu Ochiai1,*, Nobuya Hishiyama2, Shin Hisamatsu3, Nobuyuki Kanemaki4 |
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1Research Institute of Biosciences, 2Laboratory of Pathobiochemistry, School of Veterinary Medicine, and 3Laboratory of Environmental Chemistry, College of Environmental Health, and 4Veterinary Teaching Hospital, Azabu University, Kanagawa 229-8501, Japan
* ochiaih@azabu-u.ac.jp |
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We investigated the expression of aquaporin 1 (AQP1) in
tissues from canines with an inherited anomaly that causes
their erythrocytes to have high K+. Northern blot analysis
revealed abundant AQP1 expression in lung and kidney,
though little expression was found in spleen. Using anti-
C-terminus for dog AQP1, abundant expression was
shown in kidney, trachea, and eye, but little expression
was shown in pancreas and cerebrum, indicating that
AQP1 expression in canine tissues is similar to that noted
in other mammals.
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