J Vet Sci. 2008 Dec;9(4):433-435   
 

Efficiency of Matricaria chamomilla CH12 and number of doses of rabies vaccine on the humoral immune response in cattle

Luis Souza Lima de Souza Reis1,*, Neuza Maria Frazatti-Gallina2, Rosana de Lima Paoli2, Rogerio Giuffrida3, Avelino Albas4, Eunice Oba5, Paulo Eduardo Pardo1
 

1Universidade do Oeste Paulista-UNOESTE, Pos-graduçao em Ciencia Animal, Presidente Prudente-SP, CEP 19067-175, Brasil
2Seçao de Raiva do Instituto Butantan, Sao Paulo-SP, CEP 05503-900, Brasil
3Universidade do Oeste Paulista, UNOESTE, Laboratorio de Medicina Veterinaria Preventiva, Presidente Prudente-SP, CEP 19067-175, Brazil
4Agencia Paulista de Tecnologia dos Agronegocios, Presdente Prudente, Sao Paulo, CEP 19100-000, Brasil
5Universidade Estadual Paulista Julio de Mesquita Filho-UNESP/FMVZ, Departamento de Reproduçao Animal e Radiologia, Botucatu, Sao Paulo, CEP 18618-000, Brasil
* jeongks@knu.ac.kr
 

This study evaluated the effect of Matricaria chamomilla and vaccination frequency on cattle immunization against rabies. Four groups (n = 15 /group) were treated with or without Matricaria chamomilla CH12 and vaccinated with one or two doses of rabies vaccine (30 day interval). No effect of chamomile was found on cattle immunization against rabies; however, antibody titers were protective in cattle vaccinated twice, while 93.3% of cattle vaccinated only once had titers under 0.5 UI/ml after 60 days. In conclusion, the use of chamomile did not alter the humoral immune response in cattle, and two vaccine doses are suggested for achieving protective antibody titers.