J Vet Sci. 2008 Mar;9(1):9-14   
 

Decrease in intestinal endocrine cells in Balb/c mice with CT-26 carcinoma cells

Kwang-Ho Cho1, Hyeung-Sik Lee2, Sae-Kwang Ku3,4,*
 

1Department of Radiological Science, College of Health Science, Catholic University of Daegu, Daegu 712-702, Korea
2Department of Herbal Biotechnology, Daegu Haany University, Gyeongsan 712-715, Korea
3Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, Gyeongsan 712-715, Korea
4Development Team for The New Drug of Oriental Medicine (BK21 Program), Daegu Haany University, Gyeongsan 712-715, Korea
* gucci200@hanmail.net
 

The density of intestinal endocrine cells, in Balb/c mice with colon 26 (CT-26) carcinoma cells, were examined immunohistochemically at 28 days after implantation. After CT-26 cell administration there was a significant decrease in most of the intestinal endocrine cells (p £¼ 0.01) compared with the control group. The significant quantitative changes in the intestinal endocrine cell density might contribute to the development of the gastrointestinal symptoms commonly encountered in cancer patients.