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- J Vet Sci. 2009 Jun;10(2):165-167
DOI: 10.4142/jvs.2009.10.2.165 |
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A novel ¥â-glucan produced by Paenibacillus polymyxa JB115 induces
nitric oxide production in RAW264.7 macrophages
Zhi-Qiang Chang1, Joong-Su Lee1, Mi-Hyun Hwang1, Joo-Heon Hong2, Hee-Kyoung Jung2, Sam-Pin Lee3,
Seung-Chun Park1,* |
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1College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea
2Bio Industry Center, Daegu Technopark, Daegu 704-701, Korea
3Department of Food Science and Technology, Keimyung University, Daegu 704-701, Korea
* parksch@knu.ac.kr |
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The effect of extracellular ¥â-(1¡æ3), (1¡æ6)-glucan, produced
by Paenibacillus polymyxa JB115, on nitric oxide (NO)
production in RAW264.7 macrophages was investigated.
¥â-glucan induced the production of NO by RAW264.7
macrophages in a concentration- and time-dependent manner.
Moreover, ¥â-glucan stimulation increased the mRNA expression
of iNOS, COX-2 and IL-6 in RAW264.7 macrophages in a
concentration-dependent manner.
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