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- J Vet Sci. 2009 Jun;10(3):177-180
DOI: 10.4142/jvs.2009.10.3.177 |
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Immunohistochemical localization of galectin-3 in the granulomatous
lesions of paratuberculosis-infected bovine intestine
Juyeon Lee1,Changjong Moon2, Jihoon Kim1, Chanwoo Jung1, Keun-Hwa Lee3, Hong-Gu Joo1, Meejung Ahn1, Taekyun Shin1,* |
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1Department of Veterinary Anatomy, College of Veterinary Medicine and Applied Radiological Science Research Institute, Jeju National University, Jeju 690-756, Korea
2Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, Korea
3Department of Microbiology, College of Medicine, Jeju National University, Jeju 690-756, Korea
* shint@cheju.ac.kr |
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The presence of galectin-3 was immunohistochemically
quantified in bovine intestines infected with paratuberculosis
(Johne¡¯s disease) to determine whether galectin-3 was
involved in the formation of granulation tissue associated
with the disease. Mycobacterium avium subsp. paratuberculosis
infection was histochemically confirmed using Ziehl-
Neelsen staining and molecularly diagnosed through rpoB
DNA sequencing. Galectin-3 was detected in the majority
of inflammatory cells, possibly macrophages, in the
granulomatous lesions within affected tissues, including
the ileum. These findings suggest that galectin-3 is associated
with the formation of chronic granulation tissues in bovine
paratuberculosis, probably through cell adhesion and
anti-apoptosis mechanisms.
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