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- J Vet Sci. 2009 Jun;10(3):239-247
DOI: 10.4142/jvs.2009.10.3.239 |
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The effect of doxycycline on canine hip osteoarthritis: design of a 6-
months clinical trial
Korakot Nganvongpanit1,3,*, Peraphan Pothacharoen3, Niyada Suwankong1,2, Siriwan Ong-Chai1,3, Prachya Kongtawelert1,3 |
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1Bone and Joint Research Laboratory, Department of Veterinary Biosciences and Public Health, and 2Department of Small Animal Clinic, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand
3Thailand Excellence Center for Tissue Engineering, Department of Biochemistry, Faculty of Medicine, Chiang Mai
University, Chiang Mai 50000, Thailand
* korakot@chiangmai.ac.th |
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Twenty-five dogs were included in a randomized, doubleblind
trial to assess the efficacy of doxycycline (DOX) orally
administered twice a day at 4 mg/kg/day (n = 12) for the
treatment of osteoarthritis of the hip. Chondroitin sulfate
(CS; 525 mg/day) was used as a positive control (n = 13).
Dogs were re-examined monthly for 6 months after initiation
of treatment. The assessment protocol included clinical
score, radiographic findings and serum osteoarthritis
biomarkers. Dogs treated with DOX showed statistically
significant improvements (p £¼ 0.05) in lameness, joint
mobility, pain on palpation, weight-bearing and overall
score at 2, 6, 4, 4 and 4 months, respectively, after treatment.
Biomarker levels of CS-WF6 epitope and hyaluronan were
significantly increased and decreased (p £¼ 0.05) at 2 and 3
months after treatment compared to pretreatment. These
results showed that DOX had a positive therapeutic effect in
dogs with osteoarthritis.
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