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- J Vet Sci. 2009 Jun;10(4):299-304
DOI: 10.4142/jvs.2009.10.4.299 |
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Infrared spectroscopy characterization of normal and lung cancer cells
originated from epithelium
So Yeong Lee1, Kyong-Ah Yoon2, Soo Hwa Jang1, Erdene Ochir Ganbold3, Dembereldorj Uuriintuya3, Sang-Mo Shin4, Pan Dong Ryu1, Sang-Woo Joo3,* |
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1Laboratory of Pharmacology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea
2Research Institute and Hospital, National Cancer Center, Goyang 410-769, Korea
3Department of Chemistry, Soongsil University, Seoul 156-743, Korea
4Department of Mechatronics, Gwangju Institute of Science and Technology, Gwangju 500-712, Korea
* sjoo@ssu.ac.kr |
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The vibrational spectral differences of normal and lung
cancer cells were studied for the development of effective
cancer cell screening by means of attenuated total reflection
infrared spectroscopy. The phosphate monoester symmetric
stretching ¥ís(PO32-) band intensity at ¡970 cm-1 and the
phosphodiester symmetric stretching ¥ís(PO2-) band intensity
at ¡1,085 cm-1 in nucleic acids and phospholipids appeared
to be significantly strengthened in lung cancer cells with
respect to the other vibrational bands compared to normal
cells. This finding suggests that more extensive
phosphorylation occur in cancer cells. These results
demonstrate that lung cancer cells may be prescreened
using infrared spectroscopy tools.
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