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- J Vet Sci. 2009 Jun;10(2):93-98 DOI: 10.4142/jvs.2009.10.2.93 |
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Imaging evaluation of the liver using multi-detector row computed
tomography in micropigs as potential living liver donors
Jung Min Ryu1, Dong Hyun Kim2, Min Young Lee1, Sang Hun Lee1, Jae Hong Park1, Seung Pil Yun1, Min Woo Jang1, Seong Hwan Kim3, Gyu Jin Rho4, Ho Jae Han1,* |
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1Department of Veterinary Physiology, College of Veterinary Medicine, Biotherapy Human Resources Center (BK21), Chonnam National University, Gwangju 500-757, Korea
2Department of Diagnostic Radiology, College of Medicine, Chosun University Hospital, Gwangju 501-759, Korea
3Department of Surgery, College of Medicine, Chosun University Hospital, Gwangju 501-759, Korea
4College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, Korea
* hjhan@chonnam.ac.kr |
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The shortage of organ donors has stimulated interest in
the possibility of using animal organs for transplantation
into humans. In addition, pigs are now considered to be the
most likely source animals for human xenotransplantation
because of their advantages over non-human primates.
However, the appropriate standard values for estimations
of the liver of micropigs have not been established. The
determination of standard values for the micropig liver
using multi-detector row computed tomography (MDCT)
would help to select a suitable donor for an individual
patient, determine the condition of the liver of the micropigs
and help predict patient prognosis. Therefore, we
determined the standard values for the livers of micropigs
using MDCT. The liver parenchyma showed homogenous
enhancement, and had no space-occupying lesions. The
total and right lobe volumes of the liver were 698.57 กพ 47.81
ml and 420.14 กพ 26.70 ml, which are 51.74% and 49.35% of
the human liver volume, respectively. In micropigs, the
percentage of liver volume to body weight was
approximately 2.05%. The diameters of the common
hepatic artery and proper hepatic artery were 6.24 กพ 0.20
mm and 4.68 กพ 0.13 mm, respectively. The hepatic vascular
system of the micropigs was similar to that of humans,
except for the variation in the length of the proper hepatic
artery. In addition, the diameter of the portal vein was
11.27 กพ 0.38 mm. In conclusion, imaging evaluation using
the MDCT was a reliable method for liver evaluation and its
vascular anatomy for xenotransplantation using micropigs.
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