Analgesic efficacy of oral firocoxib in ovariohysterectomized cats
Prangtip Phuwapattanachart, Naris Thengchaisri*
Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Lat Yao, Chatuchak, Bangkok, 10900 Thailand
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Received: January 25, 2016; Revised: June 5, 2016; Accepted: July 21, 2016; Published online: August 10, 2016.
The post-operative analgesic effects of firocoxib in ovariohysterectomized cats were observed. Twenty-four cats were divided into 3 groups: control (no medicine), firocoxib-1 (1 mg/kg/day) and firocoxib-3 (3 mg/kg/day). Colorado pain scale scores (CPSS), composite pain scores (CPS), and buccal mucosal bleeding times (BMBT) were recorded in blinded fashion before induction and 2, 5, 8, 24, 30, and 48 hours post-operation. The average post-operative CPSS (mean±SEM) from 2 to 48 hours post-operation in firocoxib-3 (0.4±0.1) was significantly lower than those of the control (0.7±0.2; P-value = 0.004), but that of firocoxib-1 (0.5±0.2) was not different from control (P-value=0.40). The average CPS of the firocoxib-3 were significantly lower than those of the control at 24 hours post-operation (P-value = 0.04), nonetheless, there was no significant difference in average composite pain scores between firocoxib-1 and control at all intervals. The average BMBT and body temperature were in normal limit in all groups. However, a reversible azotemia was identified in 2 cats from the firocoxib-3 at 72 hours post-operation. One cat from the firocoxib-3 vomited once at 48 hours post-operation. In conclusions, firocoxib-3 is helpful for post-operative pain control in cats; however, gastrointestinal irritation and renal function side effects may occur.