Antigenic characterization of classical swine fever virus YC11WB isolates from wild boar
Seong-In Lim1, Yong Kwan Kim1, Ji-Ae Lim1, Song-Hee Han1, Hee-Suk Hyun1, Ki-Sun Kim1, Bang-Hun Hyun1, Jae-Jo Kim1, In-Soo Cho1, Jae-Young Song1, Sung-Hyun Choi2, Seung-Hoe Kim2, Dong-Jun An1,*
1Animal and Plant Quarantine Agency, Gimcheon, Gyeongbuk, 39660, Republic of Korea
2Korea Pork Producers Association, Seoul, 137-726, Republic of Korea
Correspondence to: Tel: +82-31-467-1782; Fax: +82-31-467-1800; E-mail: andj67@korea.kr
Received: February 17, 2016; Revised: June 21, 2016; Accepted: July 21, 2016; Published online: August 10, 2016.
Abstract
Classical swine fever (CSF), a highly contagious disease that affects domestic pigs and wild boar, has serious economic implications. The present study examined the virulence and transmission of strain YC11WB (isolated from a wild boar in 2011) in breeding wild boar. Virulence in domestic pigs was also examined. Based on the severe clinical signs and high mortality observed among breeding wild boar, the pathogenicity of strain YC11WB resembled that of typical acute CSF. Surprisingly, in contrast to strain SW03 (isolated from breeding pigs in 2003), strain YC11WB also showed both acute and strong virulence in breeding pigs. None of three specific monoclonal antibodies (7F2, 7F83, and 6F65) raised against the B/C domain of the SW03 E2 protein bound to the B/C domain of strain YC11WB due to amino acid mutations (720K→R and 723N→S) in the YC11WB E2 protein. Although strains YC11WB and SW03 belong to subgroup 2.1b, they showed different mortality rates in breeding pigs. Thus, if breeding pigs have not developed protective immunity against classical swine fever virus, they may be susceptible to YC11WB transmitted by wild boar, resulting in severe economic losses for the pig industry.
Keywords: Classical swine fever virus, Domain, Pathogenicity, Wild boar


© 2016 The Korean Society of Veterinary Science.