Tissue distribution of marbofloxacin in pigs after a single intramuscular injection
Fan Yang1,*,†, Yiming Liu2,†, Zhili Li3, Yuqin Wang1, Baobao Liu1, Zhensheng Zhao1, Bianhua Zhou1, Guoyong Wang1
1College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, PR China
2Key Laboratory for Feed Biotechnology of the Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 10081, PR China
3College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, PR China
Correspondence to: Tel: +86 0379 69884468; E-mail: yfscau@126.com
The first two authors contributed equally to this work.
Received: February 23, 2016; Revised: May 28, 2016; Accepted: July 21, 2016; Published online: August 10, 2016.
Abstract
Tissue distribution of marbofloxacin was studied in pigs after a single intramuscular injection at 2.5 mg/kg body weight. Samples of plasma, muscle, liver, kidney, heart, lung, and muscle at the injection site were randomly collected from five pigs at 2, 6, 10, 24, 48, 72, and 96 h after administration. Marbofloxacin concentrations were determined by high-performance liquid chromatography with ultraviolet detection, and then were subjected to non-compartmental analysis to get the kinetic parameters. The elimination half-live (t1/2λz) of marbofloxacin at injection site was 22.12 h, and that in kidney, plasma, liver, lung, heart, and muscle was 16.75, 21.48, 21.84, 24.00, 24.45, and 28.91 h, respectively. Areas under the concentration-time curve from 0 h to ∞ (AUC0-∞s) were calculated to be 31.17 h?μg?mL-1, 32.97, 33.92, 34.78, 37.58, 42.02, and 98.80 h?μg?g-1 for plasma, heart, muscle, lung, liver, kidney, and injection site, respectively. The peak concentration (Cmax) of marbofloxacin was 1.62 μg?mL-1, 1.71, 1.74, 1.86, 1.93, 2.45, and 7.64 μg?g-1 in plasma, heart, lung, muscle, kidney, liver, and injection site, respectively. It was shown that marbofloxacin was fast absorbed, extensively distributed and slowly eliminated from pigs after a single intramuscular administration.
Keywords: marbofloxacin, pigs, tissue distribution, kinetic parameters


© 2016 The Korean Society of Veterinary Science.