Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor
Yawon Hwang1, Dongwook Kim1, Dongwoo Chang1, Byeongwoo Ahn1, Yun-Bae Kim1,2, Gonhyung Kim1,*
1Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea
2Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia V6T2B5, Canada
Correspondence to: Tel: +82-432613171; Fax: +82-432613224; E-mail: ghkim@cbu.ac.kr
Received: May 20, 2016; Revised: June 28, 2016; Accepted: July 21, 2016; Published online: August 10, 2016.
Abstract
This is the first case report to describe the tumor regressive effect of systemic human neural stem cells (NSCs)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared about two weeks after the 5-FC administration. Thoracic radiographs revealed a reduced number of lung nodules and decreased nodule size. However, there were no significant antitumor effects on primary lesions in the abdominal organs. In conclusion, human NSCs/5-FC prodrug therapy can secure patient quality of life with the same or more therapeutic effects and less side effects than other recommended chemotherapies.
Keywords: gene therapy, neural stem cells, 5-fluorocytosine, metastatic lung tumor


© 2016 The Korean Society of Veterinary Science.