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J. Vet. Sci. 2016; 17(4): 435-444  https://doi.org/10.4142/jvs.2016.17.4.435
Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model
Joongsun Kim1,2,*, Sunhoo Park1, Byung-Suk Jeon1, Won-Seok Jang1, Sun-Joo Lee1, Yeonghoon Son2, Kyung-Jin Rhim3, Soong In Lee4, Seung-Sook Lee1,*
1Laboratory of Radiation Exposure & Therapeutics, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea
2Research Center, Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Busan 46033, Korea
3Department of Dermatology, Korea Institute of Radiological & Medical Sciences (KIRAMS), Seoul 01812, Korea
4College of Oriental Medicine, Dongshin Univiersity, Naju 58245, Korea
Correspondence to: Seung-Sook Lee
Tel: +82-2-970-2011; Fax: +82-2-970-2404;
E-mails: sslee@kcch.re.kr (SS Lee), jskim@dirams.re.kr (JS Kim)
Received: September 25, 2015; Revised: February 2, 2016; Accepted: March 4, 2016; Published online: December 30, 2016.
Abstract
Curcumin protects the skin against radiation-induced epidermal damage and prevents morphological changes induced by irradiation skin, thereby maintaining the epidermal thickness and cell density of basal layers. In this study, the effects of topical curcumin treatment on radiation burns were evaluated in a mini-pig model. Histological and clinical changes were observed five weeks after radiation exposure to the back (60Co gamma-radiation, 50 Gy). Curcumin was applied topically to irradiated skin (200 mg/cm2) twice a day for 35 days. Curcumin application decreased the epithelial desquamation after irradiation. Additionally, when compared to the vehicle-treated group, the curcumin-treated group showed reduced expression of cyclooxygenase-2 and nuclear factor-kappaB. Furthermore, irradiation prolonged healing of biopsy wounds in the exposed area, whereas curcumin treatment stimulated wound healing. These results suggest that curcumin can improve epithelial cell survival and recovery in the skin and therefore be used to treat radiation burns.
Keywords: curcumin, mini-pig, radiation burns, skin


© 2016 The Korean Society of Veterinary Science.