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J. Vet. Sci. 2016; 17(4): 549-553  https://doi.org/10.4142/jvs.2016.17.4.549
Effects of cetirizine in dogs with chronic atopic dermatitis: a randomized, double blind, placebo-controlled trial
Yun-Hsia Hsiao1,*, Charles Chen1, Ton Willemse2
1Asian Referral Center, Taipei 106, Taiwan
2Faculty of Veterinary Medicine, Utrecht University, 3584 CM Utrecht, The Netherlands
Correspondence to: Yun-Hsia Hsiao
Tel: +886-2-2708-1488; Fax: +886-2-2705-0380;
E-mail: hsiao.derm@gmail.com
Received: December 14, 2015; Revised: March 3, 2016; Accepted: May 10, 2016; Published online: December 30, 2016.
Abstract
This study was conducted to evaluate the effects of cetirizine in dogs with atopic dermatitis (AD) while fulfilling Favrot’s diagnostic clinical criteria. Dogs received either 3 mg/kg cetirizine (n = 27), or a placebo (n = 23) orally once daily for 14 days in a randomized, double blind, placebo-controlled study, without concomitant medication. The effects were evaluated using a pruritus visual analog scale at the start (day 0) and at day 14. After 14 days, cetirizine clearly had no effect on the pruritus in dogs with chronic AD, and there was no significant difference between groups. These findings indicated that cetirizine (and likely H1 histamine receptor antagonists in general) should not be recommended for the control of pruritus in dogs with long term allergies.
Keywords: atopic dermatitis, cetirizine, dogs, placebo-controlled study


© 2016 The Korean Society of Veterinary Science.