Retrospective evaluation of circulating thyroid hormones in critically ill dogs with systemic inflammatory response syndrome
Massimo Giunti*, Roberta Troia, Mara Battilani, Luciana Giardino, Francesco Dondi, Giulia Andreani, Federico Fracassi
Department of Veterinary Medical Sciences, Alma Mater Studiorum - University of Bologna, Ozzano dell’Emilia, Italy
Correspondence to: Tel: +39-5120973059, Fax: +39-512097593; E-mail: massimo.giunti@unibo.it
Received: February 2, 2016; Revised: August 9, 2016; Accepted: November 23, 2016; Published online: January 4, 2017.
Abstract
Critical illness can be associated with transient alterations in circulating thyroid hormones concentration indicating Non-Thyroidal Illness (NTI). NTI is well described in humans; literature concerning its occurrence and prognostic significance in dogs remains limited. The aim of this retrospective study was to assess the occurrence of NTI in a population of dogs with Systemic Inflammatory Response Syndrome (SIRS), and to investigate its association with disease severity (Apple Fast Score). A total of 41 SIRS dogs (acute pancreatitis n=10; parvovirus n=22; septic peritonitis n=9) were included, and divided according to SIRS origin (non-septic SIRS: acute pancreatitis; septic-SIRS: parvovirus and septic peritonitis) and final outcome (survivors, n=37; non-survivors, n=4). Healthy age-matched dogs (n=15) were included as controls. Serum thyroid hormones including total T3, free T3, total T4 and reverse T3 were measured upon admission. Significant alterations in serum thyroid hormones concentrations were documented in SIRS dogs, suggesting the presence of NTI compared to controls. Septic-SIRS dogs had a higher Apple Fast Score and lower serum thyroid hormones concentrations compared to non-septic SIRS and controls. In conclusion, NTI seems to be frequent in dogs with SIRS, and possibly associated with the presence of sepsis or higher illness severity.
Keywords: canine, non-thyroidal illness, systemic inflammation,thyroid hormones


© 2017 The Korean Society of Veterinary Science.