• home
  • articles
  • authors
  • Reviewers
  • About the Journal
  • About the Journal
  • About the Journal
  • About the Journal
  • About the Journal
  • e-Submission

Indexed/Covered by

Are pulmonary haemostasis and fibrinolysis out of balance in equine chronic pneumopathies?
Ann Kristin Barton1,*, Caroline Wirth1, Angelika Bondzio2, Ralf Einspanier2, Heidrun Gehlen1
1Equine Clinic, and 2Institute of Veterinary Biochemistry, Freie Universitaet Berlin, 14163 Berlin, Germany
Correspondence to: Tel: +49-177-7879733; Fax: +49-30-838-62529; E-mail: Ann-Kristin.Barton@fu-berlin.de
Received: March 2, 2016; Revised: September 28, 2016; Accepted: October 21, 2016; Published online: January 4, 2017.
Results of clinical examination, bronchoalveolar lavage fluid (BALF) cytology, acute phase proteins and markers of pulmonary haemostasisand fibrinolysis (fibrinogen, serum amyloid A, D-dimers) were compared between controls and horses affected by respiratory disease. Using a clinical scoring system, 58 horses were classified as free of respiratory disease (controls, n=15), recurrent airway obstruction (RAO, n=18), inflammatory airway disease (IAD, n=14) or chronic interstitial pneumopathy (CIP, n=11). No significant differences were found in fibrinogen concentration, but descriptive data analysis showed a trend towards lower values for controls (median 0.0024g/l) compared to chronic pneumopathies (median 0.0052g/l), in particular RAO (median 0.0062g/l). Fibrinogen concentration was positively correlated with the percentage of neutrophils in BALF cytology (rs=0.377, p=0.004). SAA concentrations were very low and in 65.5% of samples below the limit of detection. D-dimer concentrations were also very low and quantifiable concentrations could only be measured after ultrafiltration and only in RAO (median 0.1 mg/l). In conclusion, there was only slight evidence of increased coagulatory activity in equine chronic pneumopathies apart from RAO. It remains speculative, if fibrinogen and D-dimers are increased due to their role as acute-phase proteins or if the data may be interpreted as a misbalance of coagulation and fibrinolysis.
Keywords: chronic interstitial pneumopathy, horse, inflammatory airway disease, inflammatory marker, recurrent airway obstruction,

© 2017 The Korean Society of Veterinary Science.