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Pathogenesis of coxsackievirus B2 in mice: characterisation of clinical isolates of the coxsackievirus B2 from patients with myocarditis and aseptic meningitis in Korea
JiYoung Hong1,2,*, BungHak Kang3, SangGu Yeo3, Youngmee Jee3, Jae-Hak Park1,*
1Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea
2Vaccines division, National Institute of Food & Drug Safety Evaluation, Ministry of Food and Drug Safety, Cheongju 28159, Republic of Korea
3Division of Vaccine Research, Center for Infectious Disease, National Institute of Health, Korea Center for Diseases Control and Prevention, Cheongju 28159, Republic of Korea
Correspondence to: Tel: +82-2-880-1256; Fax: +82-2-887-1257; E-mails: pjhak@snu.ac.kr (JH Park), ecadee81@korea.kr (JY Hong)
Received: April 18, 2016; Revised: December 14, 2016; Accepted: February 7, 2017; Published online: April 6, 2017.
Group B coxsackieviruses (CVBs) are a group of common human pathogens causing various clinical symptoms. Although the virology of CVB is well known, there is limited information on viral pathogenesis and the relationship between clinical symptoms and viral phenotype, particularly for CVB type 2 (CVB2). In this study, two CVB2 strains were isolated: CB2/04/279 from a stool of an acute myocarditis patient with heart failure; and CB2/04/243 from an aseptic meningitis patient in 2004 in Korea. A high degree of homology was observed between the CB2/04/279 and CB2/04/243 full genome sequences. The two Korean CVB2 isolates had 93.1% homology compared to 82.1–82.5% nucleotide sequence identity with the cardiovirulence-associated reference CVB strain Ohio-1 (CVB/O). CVB2-induced pathogenesis was analyzed, with a focus on virus-induced pathology of various tissues in 4-week-old BALB/c inbred male mice. Myocarditis was developed, and an extensive pancreatic inflammation was seen in all mice infected with CB2/04/279 or CVB/O, but not in animals infected with CB2/04/243. This is the first report of the full-genomic sequence and pathogenesis of the CVB2 strain isolated from an acute myocarditis patient in Korea.
Keywords: Coxsackievirus B2, Myocarditis, Cardiovirulence, Pathogenesis

© 2017 The Korean Society of Veterinary Science.