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Use of stem cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a toy poodle
Jaeyong Song1,†, Yongsun Kim2,†, Oh-Kyeong Kweon2, Byung-Jae Kang1,*
1College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, 24341, Korea
2Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Korea
Correspondence to: Tel: +82-33-250-8207; Fax: +82-33-259-5625; E-mail: bjkang@kangwon.ac.kr
The first two authors contributed equally to this work.
Received: August 29, 2016; Revised: December 27, 2016; Accepted: February 7, 2017; Published online: April 6, 2017.
Abstract
A 12-year-old castrated Toy Poodle was referred to Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the left distal 1/3 of the radius and an intact ulna. After fixation using a locking plate and screws, adipose-derived mesenchymal stem cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture healed at 9 weeks after surgery. In the present case, the mesenchymal stem cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.
Keywords: adipose-derived mesenchymal stem cells, bone morphogenetic protein 7, dog, nonunion, radial fracture


© 2017 The Korean Society of Veterinary Science.