Use of stem cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a toy poodle
Jaeyong Song1,†, Yongsun Kim2,†, Oh-Kyeong Kweon2, Byung-Jae Kang1,*
1College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon, 24341, Korea
2Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul, 08826, Korea
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The first two authors contributed equally to this work.
Received: August 29, 2016; Revised: December 27, 2016; Accepted: February 7, 2017; Published online: April 6, 2017.
A 12-year-old castrated Toy Poodle was referred to Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the left distal 1/3 of the radius and an intact ulna. After fixation using a locking plate and screws, adipose-derived mesenchymal stem cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture healed at 9 weeks after surgery. In the present case, the mesenchymal stem cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.
Keywords: adipose-derived mesenchymal stem cells, bone morphogenetic protein 7, dog, nonunion, radial fracture

© 2017 The Korean Society of Veterinary Science.