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J. Vet. Sci. 2017; 18(2): 169-173  https://doi.org/10.4142/jvs.2017.18.2.169
Tissue distribution of marbofloxacin in pigs after a single intramuscular injection
Fan Yang1,*,†, Yiming Liu2,†, Zhili Li3, Yuqin Wang1, Baobao Liu1, Zhensheng Zhao1, Bianhua Zhou1, Guoyong Wang1
Colleges of 1Animal Science and Technology, and 3Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China
2Key Laboratory for Feed Biotechnology of the Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 10081, China
Correspondence to: Fan Yang Tel: +86-379-69884468; Fax: +86-379-64563979; E-mail: yfscau@126.com
Received: February 23, 2016; Revised: May 28, 2016; Accepted: July 21, 2016; Published online: June 30, 2017.
Abstract
Tissue distribution of marbofloxacin was studied in pigs after a single intramuscular injection at 2.5 mg/kg body weight. Samples of plasma, muscle, liver, kidney, heart, lung, and muscle at the injection site were randomly collected from five pigs at 2, 6, 10, 24, 48, 72, and 96 h after administration. Marbofloxacin concentrations were determined by using high-performance liquid chromatography with ultraviolet detection and were subjected to non-compartmental analysis to obtain kinetic parameters. The elimination half-life (t1/2λz) of marbofloxacin at the injection site was 22.12 h, while those in kidney, plasma, liver, lung, heart, and muscle were 16.75, 21.48, 21.84, 24.00, 24.45, and 28.91 h, respectively. Areas under the concentration-time curve from 0 h to ∞ (AUC0-∞s) were calculated to be 31.17 hㆍμgㆍmL-1 for plasma and 32.97, 33.92, 34.78, 37.58, 42.02, and 98.80 hㆍμgㆍg-1 for heart, muscle, lung, liver, kidney, and injection site, respectively. The peak concentration (Cmax) of marbofloxacin was 1.62 μg/mL in plasma and 1.71, 1.74, 1.86, 1.93, 2.45, and 7.64 μg/g in heart, lung, muscle, kidney, liver, and injection site, respectively. The results show that marbofloxacin was fast absorbed, extensively distributed, and slowly eliminated from pigs after a single intramuscular administration.
Keywords: kinetic parameters, marbofloxacin, pigs, tissue distribution


© 2017 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.