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J. Vet. Sci. 2017; 18(2): 175-182  https://doi.org/10.4142/jvs.2017.18.2.175
Analgesic efficacy of oral firocoxib in ovariohysterectomized cats
Prangtip Phuwapattanachart, Naris Thengchaisri*
Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand
Correspondence to: Naris Thengchaisri Tel: +66-2-579-0058; Fax: +66-2-579-7541; E-mail: ajnaris@yahoo.com
Received: January 25, 2016; Revised: June 5, 2016; Accepted: July 21, 2016; Published online: June 30, 2017.
Abstract
The postoperative analgesic effects of firocoxib in ovariohysterectomized cats were observed. Twenty-four cats were divided into 3 groups: control (no medicine), firocoxib-1 (1 mg/kg/day) and firocoxib-3 (3 mg/kg/day). Colorado pain scale scores (CPSS), composite pain scores (CPS), and buccal mucosal bleeding times (BMBT) were recorded in blinded fashion before induction and 2, 5, 8, 24, 30, and 48 h post-operation. The average CPSS (mean ± SEM) over 2 to 48 h post-operation in firocoxib-3 (0.4 ± 0.1) was significantly lower than that of the control (0.7 ± 0.2; p = 0.004), but that of firocoxib-1 (0.5 ± 0.2) was not different from that of the control (p = 0.40). The mean CPS of firocoxib-3 was significantly lower than that of the control at 24 h post-operation (p = 0.04); nonetheless, there was no significant difference in mean CPS between firocoxib-1 and control groups at all intervals. BMBT and body temperature were within normal limits in all groups. However, reversible azotemia was identified in two firocoxib-3 cats at 72 h post-operation. One firocoxib-3 cat vomited once at 48 h post-operation. In conclusion, firocoxib-3 is helpful for postoperative pain control in cats; however, gastrointestinal irritation and renal function side effects may occur.
Keywords: analgesia, cats, cyclooxygenase, firocoxib, ovariohysterectomy


© 2017 The Korean Society of Veterinary Science.

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