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J. Vet. Sci. 2017; 18(2): 201-207  https://doi.org/10.4142/jvs.2017.18.2.201
Antigenic characterization of classical swine fever virus YC11WB isolates from wild boar
Seong-In Lim1, Yong Kwan Kim1, Ji-Ae Lim1, Song-Hee Han1, Hee-Suk Hyun1, Ki-Sun Kim1, Bang-Hun Hyun1, Jae-Jo Kim1, In-Soo Cho1, Jae-Young Song1, Sung-Hyun Choi2, Seung-Hoe Kim2, Dong-Jun An1,*
1Animal and Plant Quarantine Agency, Gimcheon 39660, Korea
2Korea Pork Producers Association, Seoul 06643, Korea
Correspondence to: Dong-Jun An Tel: +82-31-467-1782; Fax: +82-31-467-1800; E-mail: andj67@korea.kr
Received: February 17, 2016; Revised: June 21, 2016; Accepted: July 21, 2016; Published online: June 30, 2017.
Abstract
Classical swine fever (CSF), a highly contagious disease that affects domestic pigs and wild boar, has serious economic implications. The present study examined the virulence and transmission of CSF virus strain YC11WB (isolated from a wild boar in 2011) in breeding wild boar. Virulence of strain YC11WB in domestic pigs was also examined. Based on the severe clinical signs and high mortality observed among breeding wild boar, the pathogenicity of strain YC11WB resembled that of typical acute CSF. Surprisingly, in contrast to strain SW03 (isolated from breeding pigs in 2003), strain YC11WB showed both acute and strong virulence in breeding pigs. None of three specific monoclonal antibodies (7F2, 7F83, and 6F65) raised against the B/C domain of the SW03 E2 protein bound to the B/C domain of strain YC11WB due to amino acid mutations (720K→R and 723N→S) in the YC11WB E2 protein. Although strains YC11WB and SW03 belong to subgroup 2.1b, they had different mortality rates in breeding pigs. Thus, if breeding pigs have not developed protective immunity against CSF virus, they may be susceptible to strain YC11WB transmitted by wild boar, resulting in severe economic losses for the pig industry.
Keywords: B/C domain, Classical swine fever virus, Sus scrofa, virulence


© 2017 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.