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J. Vet. Sci. 2017; 18(2): 257-260  https://doi.org/10.4142/jvs.2017.18.2.257
Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor
Yawon Hwang1, Dongwook Kim1, Dongwoo Chang1, Byeongwoo Ahn1, Yun-Bae Kim1,2, Gonhyung Kim1,*
1Veterinary Medical Center, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Korea
2Division of Neurology, Department of Medicine, UBC Hospital, University of British Columbia, Vancouver, British Columbia V6T2B5, Canada
Correspondence to: Gonhyung Kim Tel: +82-432613171; Fax: +82-432613224; E-mail: ghkim@cbu.ac.kr
Received: May 20, 2016; Revised: June 28, 2016; Accepted: July 21, 2016; Published online: June 30, 2017.
This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared approximately two weeks after 5-FC administration. Thoracic radiographs revealed a reduced number of lung nodules and decreased nodule size. However, there were no significant antitumor effects on primary lesions in abdominal organs. In conclusion, human NSC/5-FC prodrug therapy can secure patient quality of life with the same or more therapeutic effects and fewer side effects than other recommended chemotherapies.
Keywords: flucytosine, gene therapy, metastatic lung tumor, neural stem cells

© 2017 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.