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Magnetic resonance imaging characteristics of ischemic brain infarction according to time passage in a canine stroke model
Sooyoung Choi1, Daji Noh2, Youngwhan Kim3, Inseong Jeong3, Hojung Choi4, Youngwon Lee4, Kija Lee2,*
1Ian Animal Diagnostic Center, Seoul 06014, Korea
2College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea
3Royal Animal Medical Center, Seoul 02117, Korea
4College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea
Correspondence to: Tel: +82-53-950-5961; Fax: +82-53-950-5955; E-mail: leekj@knu.ac.kr
Received: October 31, 2016; Revised: February 22, 2017; Accepted: March 26, 2017; Published online: July 10, 2017.
Abstract
This study describes magnetic resonance imaging findings and changes in lateral ventricular size according to time passage of canine ischemic stroke model. T1- and T2-weighted (T1W, T2W) imaging and fluid-attenuated inversion recovery (FLAIR) sequence were performed at 3 h and 3, 8, and 35 days after brain infarct induction. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient mapping were obtained at 8 and 35 days. A total of 29 brain lesions were induced successfully in 12 of 14 beagle dogs. At 3 h, T2W and FLAIR detected hyperintense lesions (3/3) in three randomly selected dogs. On T1W, lesions appeared hypo- to isointense at 3 h, iso- (18/29) or hypointense (11/29) at 3 days, hypo- to isointense with peripheral hyperintensity (24/26) at 8 days, and hypointense (18/26) at 35 days. Infarcts on DWI/ADC were hypo- to isointense centrally, with the periphery hyperintense/hyperintense (11/26) at 8 days and hypointense/hyperintense (19/26) at 35 days. A markedly increased lateral ventricular size was observed in dogs with cerebral infarcts. In conclusion, T2W and FLAIR were useful for detecting early stage (3 h to 3 days) brain infarction. T1W and DWI were useful for detecting neuronal necrosis and providing supplemental information for phase evaluation.
Keywords: dog, ischemic brain infarction, lateral ventricular size, magnetic resonance imaging, time passage


© 2017 The Korean Society of Veterinary Science.