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A new recombined PRRSV virulent strain in China
Jian-guo Dong1,2,†, Lin-yang Yu1,†, Pei-pei Wang1, Le-yi Zhang1, Yan-ling Liu1, Peng-shuai Liang1, Chang-xu Song1,*
1Animal Science College/National Engeering Center for Swine Breeding Industry, South China Agriculture University, Guangzhou, 510642, China
2Xinyang Animal Disease Prevention and Control Engineering Research Center, Xinyang College of Agriculture and Forestry, Xinyang 464000, China
Correspondence to: Tel: +86-13829723528; E-mail: cxsong2004@163.com
The first two authors contributed equally to this work.
Received: December 19, 2016; Revised: June 2, 2017; Accepted: June 29, 2017; Published online: July 10, 2017.
Abstract
Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases worldwide. In the present study, a new virulent strain of PRRS virus(PRRSV) GDsg was isolated in Guangdong province of China, which caused high fever, high morbidity and high mortality for sow and piglets. The genome of this new strain is 15,413 nucleotides(nt) in length and comparative analysis revealed that GDsg shared 82.4% to 94% identity with type 2 PRRSV strains, but only 61.5% with type 1 PRRSV strain-Lelystad Virus, Phylogenetic analysis indicated that type 2 PRRSV isolates formed five subgenotypes (I, II, III, IV, V), which was represented by NADC30, VR-2332, GM2, CH-1a and HuN4, respectively. And GDsg belonged to the newly emerging type 2 PRRSV subgenotypes III. More interestingly, the new isolated GDsg strain had multiple discontinuous nucleotide(nt) deletions 131(19+18+94) at position 1404-1540 and 107-nt insertion of NSP2 region, and most importantly, the GDsg strain was a recombined virus between low pathogenic field strain QYYZ and vaccine strain JXA1-P80. In conclusion, a new independent subgenotype and recombinant strain emerged in China, which could be a new threat to the swine industry of China.
Keywords: new subgenotype, phylogenetic analysis, porcine reproductive and respiratory syndrome virus, recombinant strain


© 2017 The Korean Society of Veterinary Science.