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Prepubertal Growth and Single Nucleotide Polymorphism Analysis of the Growth Hormone Gene of Holstein Calves born smaller
Younghye Ro1, Woojae Choi1, Hoyung Kim2, Hojin Jang3, Hoseon Lee4, Yoonseok Lee5,*, Danil Kim1,6,*
1Department of Farm Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
2University Animal Farm College of Agriculture & Life Sciences, Seoul National University, Pyeongchang 25354, Korea
3Dairy Cattle Improvement Center, National Agricultural Cooperative Federation, Goyang 10292, Korea
4Hyun-ri Animal Clinic, Gapyeong 12437, Korea
5Department of Biotechnology and Genomic Informatics Center, College of Agriculture & Life Science, Hankyong National University, Anseong 17579, Korea
6Farm Animal Clinical Training and research Center, Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea
Correspondence to: Tel: +82-33-339-6102; E-mails: danilkim@snu.ac.kr (D Kim), yoonseok95@hknu.ac.kr (Y Lee).
Received: December 26, 2016; Revised: May 3, 2017; Accepted: June 8, 2017; Published online: July 10, 2017.
Holstein calves weighing less than 20 kg at birth have been born, but no studies on small Holstein calves have been reported in South Korea. We raised small calves with age-matched normal-birth weight Holstein calves and measured body weight before puberty. Three single nucleotide polymorphisms (SNPs) of the growth hormone gene were also analyzed. Up to 10 months of age, low-birth weight calves remained undersized compared to normal calves. In exon 5 of the growth hormone, the SNP was detected in some small calves; however, this did not appear to be the only factor inducing low-birth weight and slow growth.
Keywords: Holstein calf, growth hormone, low birth weight, prepubertal growth, single nucleotide polymorphism

© 2017 The Korean Society of Veterinary Science.