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J. Vet. Sci. 2017; 18(S1): 381-384  
Experimental infection of dogs with highly pathogenic avian influenza virus (H5N8)
Seong-Su Yuk, Dong-Hun Lee, Jae-Keun Park, Erdene-Ochir Tseren-Ochir, Jung-Hoon Kwon, Jin-Yong Noh, Chang-Seon Song*
Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea
Correspondence to: Tel: +82-2-450-3712; Fax: +82-2-3437-1941; E-mail: songcs@konkuk.ac.kr
Received: August 17, 2016; Revised: January 31, 2017; Accepted: February 7, 2017; Published online: August 31, 2017.
During the highly pathogenic avian influenza (HPAI) H5N8 virus outbreak in Korea, a dog in layer farm contaminated by H5N8 was reported seropositive for HPAI H5N8. To investigate the possibility of adaptation and transmission of HPAI H5N8 to dogs, we experimentally inoculated dogs with H5N8. Viral genes were weakly detected in nasal swabs and seroconversions in inoculated and contact dogs. Although the H5N8 virus did not induced severe clinical signs to dogs, the results suggest that surveillance of farm dogs should continue as a species in which the avian influenza virus may acquire infectivity to mammals through frequent contact with the virus.
Keywords: animal experiment, dogs, influenza A virus H5N8 subtype, transmission, virulence

© 2017 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.