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J Vet Sci 2017; 18(3): 291-297  https://doi.org/10.4142/jvs.2017.18.3.291
Guanosine 5'-monophosphate-chelated calcium and iron feed additives maintains egg production and prevents Salmonella Gallinarum in experimentally infected layers
Hye-Ji Noh1, HeeKyong Kim1, Su Jeong Heo2, Hyang Hyun Cho3, Hong Bum Koh2,*
1Medinutrol Co., Ltd., Yeonggwang 57024, Korea
2College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea
3Hanilbiomed Inc., Gwangju 62363, Korea
Correspondence to: Hong Bum Koh
Tel: +82-62-530-2849; Fax: +82-62-530-2809; E-mail: hbkoh@chonnam.ac.kr
Received: August 24, 2016; Revised: September 12, 2016; Accepted: November 23, 2016; Published online: September 30, 2017.
We evaluated the effects of guanosine 5′-monophosphate (GMP)-chelated calcium and iron (CaFe-GMP) on health and egg quality in layers experimentally infected with Salmonella Gallinarum. In this study, a CaFe-GMP feed additive was added to a commercial layer feed and fed to layers over a four-week period. All were inoculated with Salmonella Gallinarum. Body weight, mortality, clinical symptoms, and poultry production including feed intake, egg production, egg loss, and feed conversion rate were observed, and Salmonella Gallinarum was re-isolated from the liver, spleen, and cecum of the layers. All tested internal organs for the CaFe-GMP additive group exhibited significantly lower re-isolation numbers of Salmonella Gallinarum and less severe pathological changes than those in the control group, indicating that the CaFe-GMP feed supplement induced bacterial clearance and increased resistance to Salmonella Gallinarum. Additionally, due to the inhibitory action of CaFe-GMP on the growth of Salmonella Gallinarum, the CaFe-GMP additive group exhibited better egg production, including a higher laying rate and fewer broken eggs. The results suggest that a 0.16% CaFe-GMP additive may help prevent salmonellosis in the poultry industry.
Keywords: Salmonella Gallinarum, feed additives, layer, organic mineral

© 2017 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.