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J Vet Sci 2017; 18(3): 333-340  https://doi.org/10.4142/jvs.2017.18.3.333
Effect of phosphorus deficiency on erythrocytic morphology and function in cows
Ziwei Zhang1, Mingyu Bi2, Jie Yang1, Haidong Yao1, Zhonghua Liu3,*, Shiwen Xu1,*
Colleges of 1Veterinary Medicine, and 3Life Science, Northeast Agricultural University, Harbin 150030, China
2Harbin Railway Public Security Bureau police dog base, Harbin 150056, China
Correspondence to: Zhonghua Liu, Shiwen Xu
Tel/Fax: +86-451-55190407; E-mails: liu086@126.com (Z Liu), shiwenxu@neau.edu.cn (S Xu)
Received: January 4, 2016; Revised: June 30, 2016; Accepted: August 26, 2016; Published online: September 30, 2017.
Abstract
The aim of this study was to evaluate the influence of phosphorus (P) deficiency on the morphological and functional characteristics of erythrocytes in cows. Forty Holstein-Friesian dairy cows in mid-lactation were randomly divided into two groups of 20 each and were fed either a low-P diet (0.03% P/kg dry matter [DM]) or a control diet (0.36% P/kg DM). Red blood cell (RBC) indices results showed RBC and mean corpuscular hemoglobin decreased while mean corpuscular volume increased significantly (p < 0.05) in P-deficient cows. Erythrocyte morphology showed erythrocyte destruction in P-deficient cows. Erythrocytes’ functional characteristics results showed total bilirubin and indirect bilirubin concentrations and aspartate transaminase and alanine transaminase activity levels in the serum of P-deficient cows were significantly higher than those in control diet-fed cows. Activities of superoxide dismutase and glutathione peroxidase in erythrocytes were lower, while the malondialdehyde content was greater, in P-deficient cows than in control diet-fed cows. Na+/K+-ATPase and Mg2+-ATPase activities were lower in P-deficient cows than in control diet-fed cows; however, Ca2+-ATPase activity was not significantly different. The phospholipid composition of the erythrocyte membrane changed and membrane fluidity rigidified in P-deficient cows. The results indicate that P deficiency might impair erythrocyte integrity and functional characteristics in cows.
Keywords: cow, erythrocyte, function, morphology, phosphorus deficiency


© 2017 The Korean Society of Veterinary Science.

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