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J Vet Sci 2017; 18(3): 349-357  https://doi.org/10.4142/jvs.2017.18.3.349
Are pulmonary hemostasis and fibrinolysis out of balance in equine chronic pneumopathies?
Ann Kristin Barton1,*, Caroline Wirth1, Angelika Bondzio2, Ralf Einspanier2, Heidrun Gehlen1
1Equine Clinic, and 2Institute of Veterinary Biochemistry, Freie Universitaet Berlin, 14163 Berlin, Germany
Correspondence to: Ann Kristin Barton
Tel: +49-177-7879733; Fax: +49-30-838-62529; E-mail: Ann-Kristin.Barton@fu-berlin.de
Received: March 2, 2016; Revised: September 28, 2016; Accepted: October 21, 2016; Published online: September 30, 2017.
Clinical examination, bronchoalveolar lavage fluid (BALF) cytology, acute-phase protein, and pulmonary hemostasis and fibrinolysis marker (fibrinogen, serum amyloid A [SAA], and D-dimer) results were compared between control and respiratory disease-affected horses. Using a clinical scoring system, horses (n = 58) were classified as respiratory disease-free (Controls, n = 15) or with recurrent airway obstruction (RAO; n = 18), inflammatory airway disease (n = 14) or chronic interstitial pneumopathy (n = 11). There were no significant differences in fibrinogen concentrations among groups, but there was a trend toward a lower value in controls (median 0.0024 g/L) than in horses with chronic pneumopathies (median 0.0052 g/L), in particular, those with RAO (median 0.0062 g/L). Fibrinogen concentration was positively correlated with percentage of neutrophils in BALF (rs = 0.377, p = 0.004). SAA concentrations were low; 65.5% of samples were below the detection limit. D-dimer concentrations were also low and quantifiable concentrations were only obtained after ultrafiltration and only in RAO (median 0.1 mg/L). In conclusion, there was limited evidence of increased coagulatory activity in chronic pneumopathies, apart from RAO. It is uncertain whether fibrinogen and D-dimer concentrations increased due to their role as acute-phase proteins or as a misbalance of coagulation and fibrinolysis.
Keywords: chronic interstitial pneumopathy, horses, inflammatory airway disease, inflammatory biomarker, recurrent airway obstruction

© 2017 The Korean Society of Veterinary Science.

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