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Comparative aspects of MicroRNA Expression in Canine and Human Cancer
Kabiru Sahabi1, Gayathri Thevi Selvarajah1,*, Rasedee Abdullah2, Cheah Yoke Kqueen3, Tan Geok Chin4
1Department of Veterinary Clinical Studies, Faculty of Veterinary Medicine,
2Department of Veterinary Laboratory Diagnostics, Faculty of Veterinary Medicine,
3Department of Biomedical Sciences, Faculty of Medicine and Biomedical Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
4Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia
Correspondence to: Tel: +603-8609 3922; Fax: +603-89471971; E-mail: gayavet@gmail.com gayathri@upm.edu.my
Received: February 7, 2017; Revised: May 19, 2017; Accepted: July 14, 2017; Published online: September 20, 2017.
Abstract
MicroRNAs (miRNAs) are important players in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. MicroRNA regulation is the most abundant mode of post-transcriptional gene regulation. MicroRNAs that are involved in the initiation and progression of cancers are termed oncomiRs, several of which have been identified in canine and human cancer. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species. In this review, current information on the expression and roles of miRNAs in oncogenesis and the progression of human and canine cancer as well the roles miRNAs play in cancer stem cells’ biology is highlighted. The potential for miRNAs as therapeutic targets for personalized cancer therapy in domestic dogs and their possible application in human cancer counterparts are also discussed.
Keywords: MicroRNA, expression, dog, cancer, stem cell


© 2017 The Korean Society of Veterinary Science.