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Differential and correlated expression of p16/p21/p27/p38 in mammary gland tumors of aged dogs
Hyun-Woo Kim, Jong-Il Shin, Byung-Joon Seung, Jung-Hyung Ju, Jung-Hyang Sur*
Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Korea
Correspondence to: Tel: +82-2-450-4153; Fax: +82-2-455-8124; E-mail: jsur@konkuk.ac.kr
Received: April 24, 2017; Revised: July 6, 2017; Accepted: July 14, 2017; Published online: September 20, 2017.
Abstract
The inhibitory effect of neutering on mammary gland tumor development in dogs is well known. However, we found that the effect of neutering on tumor malignancy may be altered by aging. Therefore, we aimed to characterize mammary tumors in aged dogs by analyzing the expression of cellular senescence markers, from the viewpoint of senescence. The expression of p16, p38, p21, and p27 antibodies, which are senescence-associated markers, was detected in canine mammary tumors of aged dogs via immunohistochemistry. In addition, the correlation between their expression was analyzed. p16 expression was negatively associated with strong nuclear p27 expression. p38 expression was observed in most of the mammary tumors examined. Furthermore, negative p38 expression was related to positive p21 expression. p21 expression was associated with p27 expression: negative p21 expression was associated with negative p27 expression, while positive p21 expression was associated with positive p27 expression. It was confirmed that the p21- and p27-encoding genes showed similar expression patterns in the mammary tumors of aged dogs. In the present study, we characterized the expression of cellular senescence markers in these tumors, and elucidated the relationships between their expression patterns.
Keywords: age; neuter; canine; mammary; tumor; cellular senescence


© 2017 The Korean Society of Veterinary Science.