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A Comparison of the Effects of Isoflurane versus Propofol-Remifentanil Anesthesia on Oxygen Delivery during Thoracoscopic Lung Lobectomy with One Lung Ventilation in Dogs
1Department of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Republic of Korea
Correspondence to: Tel: +82-42-821-6763; Fax: +82-42-821-6703 (fax), E-mail: jsmok@cnu.ac.kr
Received: May 15, 2017; Revised: August 26, 2017; Accepted: November 16, 2017; Published online: November 23, 2017.
- Abstract
- This study compared effects of isoflurane inhalation (ISO) and propofol-remifentanil combined total intravenous anesthesia (TIVA) on oxygenation during thoracoscopic lung lobectomy with 30-minute one-lung ventilation (1LV). Thoracoscopic right middle lung lobectomy was performed in ten dogs divided into ISO and TIVA group and cardiopulmonary parameters were measured with blood gas analysis. Throughout the study, isoflurane was inhaled up to 1.5%, and the infusion rates of propofol and remifentanil were 0.2~0.4 mg/kg/min and 6~11 mcg/kg/hr. Cardiac index was not affected in ISO group, while it increased during 1LV in TIVA group. There were significant alterations in arterial oxygen pressure, arterial oxygen saturation, oxygen content, and shunt fraction associated with 1LV in each group. However, oxygen delivery did not decrease significantly due to any of the open chest condition, 1LV, or the surgical maneuver in both groups, rather it increased during 1LV in TIVA group. All these parameters showed no significant difference between groups. Pulmonary vascular resistant index was not affected in each group and there was no difference between groups except in re-ventilation phase. Accordingly, the effect of both anesthetic regimens on oxygenation was not different between groups and can be used with short-term 1LV for thoracoscopic lung lobectomy in dogs.
- Keywords: isoflurane, propofol-remifentanil, thoracoscopic lung lobectomy, one lung ventilation, dog
