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J Vet Sci 2017; 18(4): 555-558  https://doi.org/10.4142/jvs.2017.18.4.555
Use of stem-cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a Toy Poodle
Jaeyong Song1,†, Yongsun Kim2,†, Oh-Kyeong Kweon2, Byung-Jae Kang1,*
1Department of Veterinary Surgery, College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Korea
2Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
Correspondence to: Byung-Jae Kang
Tel: +82-33-250-8207; Fax: +82-33-259-5625; E-mail: bjkang@kangwon.ac.kr
The first two authors contributed equally to this work.
Received: August 29, 2016; Revised: December 27, 2016; Accepted: February 7, 2017; Published online: December 31, 2017.
Abstract
A 12-year-old castrated Toy Poodle was referred to the Kangwon National University Animal Hospital with an oligotrophic nonunion fracture in the distal 1/3 of the left radius and an intact ulna. After fixation by a locking plate and screws, adipose-derived mesenchymal stem-cell sheets expressing bone morphogenetic protein 7 (BMP-7) were transplanted to the fracture site to enhance the healing activity. The fracture was healed at 9 weeks after surgery. In the present case, the mesenchymal stem-cell sheets expressing BMP-7 promoted bone regeneration and healing in a nonunion fracture.
Keywords: adipose-derived mesenchymal stromal cells, bone morphogenetic protein 7, dogs, ununited fractures


© 2017 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.