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J Vet Sci 2017; 18(4): 487-497  https://doi.org/10.4142/jvs.2017.18.4.487
KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis
Myung Geun Kook1,2, Soon Won Choi1,2, Yoojin Seo1,2, Dong Woung Kim3, Bong Keun Song4, Ilhong Son5, Sungchul Kim6,*, Kyung-Sun Kang1,2,*
1Adult Stem Cell Research Center, College of Veterinary Medicine, and 2Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
3Center of Integrative Medicine, Department of Internal Medicine, Wonkwang University Gwangju Hospital, and 6ALS/MND Center of Wonkwang University Korean Medical Hospital, Wonkwang University Gwangju Medical Center, Gwangju 61729, Korea
4Department of Internal Medicine, School of Oriental Medicine, Wonkwang University, Iksan 54538, Korea
5Department of Neurology, Inam Neuroscience Research Center, Wonkwang Univ. Sanbon Hospital, Gunpo 15865, Korea
Correspondence to: Kyung-Sun Kang, Sungchul Kim
Tel: +82-2-880-1298; Fax: +82-2-876-7610; E-mails: kangpub@snu.ac.kr (KS Kang), kscndl@hanmail.net (S Kim)
Received: July 14, 2016; Revised: December 27, 2016; Accepted: February 7, 2017; Published online: December 31, 2017.
Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective death of motor neurons in the central nervous system. The main cause of the disease remains elusive, but several mutations have been associated with the disease process. In particular, mutant superoxide dismutase 1 (SOD1) protein causes oxidative stress by activating glia cells and contributes to motor neuron degeneration. KCHO-1, a novel herbal combination compound, contains 30% ethanol and the extracts of nine herbs that have been commonly used in traditional medicine to prevent fatigue or inflammation. In this study, we investigated whether KCHO-1 administration could reduce oxidative stress in an ALS model. KCHO-1 administered to ALS model mice improved motor function and delayed disease onset. Furthermore, KCHO-1 administration reduced oxidative stress through gp91phox and the MAPK pathway in both classically activated microglia and the spinal cord of hSOD1G93A transgenic mice. The results suggest that KCHO-1 can function as an effective therapeutic agent for ALS by reducing oxidative stress.
Keywords: amyotrophic lateral sclerosis, gp91phox, neurodegenerative diseases, oxidative stress, traditional medicine


© 2017 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.