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Double filtration plasmapheresis in the treatment of hyperproteinemia in dogs affected by Leishmania infantum
Francesca Perondi1,*, Claudio Brovida2, Gianila Ceccherini1, Grazia Guidi1, Ilaria Lippi1
1Dipartimento di Scienze Veterinarie, Università di Pisa, Via Livornese lato monte, 56122 San Piero a Grado (PI), Italy
2ANUBI, Companions Animal Hospital, Moncalieri, Italy
Correspondence to: Tel: 050-2210100, E-mail: f.perondi87@gmail.com
Received: August 1, 2017; Revised: October 23, 2017; Accepted: November 24, 2017; Published online: December 28, 2017.
Three dogs were evaluated for severe hyperproteinemia and hyperglobulinemia secondary to Leishmania infantum. Double filtration plasmapheresis (DFPP) was performed in two dogs at day 1, 2 and 6 after presentation (T0). The third dog received two treatments of DFPP at day 1 and 3, and eleven hemodialysis treatments to support renal function. A significant reduction in serum total protein (p〈0.0001), alpha-1 (p〈0.023), alpha-2 (p〈0.018), gamma globulins (p=0.0105), and a significant increase in albumin/globulin ratio (p=0.0018) were found between the pre and post-treatment samples for all dogs. These findings were accompanied by the resolution of clinical signs. DFPP seemed to be a safe technique, which allowed depuration of the patient’s own plasma, with no need of substitution solution. DFPP may represent a promising therapeutic technique for rapid resolution of signs of hyperproteinemia in dogs affected by Leishmania infantum.
Keywords: Leishmania Infantum, hyperproteinemia, double filtration plasmapheresis, dog

© 2017 The Korean Society of Veterinary Science.