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Detection of hepatitis E virus genotypes 3 and 4 in pig farms in Korea
Yong-Hyun Kim, Byung-Joo Park, Hee-Seop Ahn, Sang-Hoon Han, Hyeon-Jeong Go, Dong-Hwi Kim, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, In-Soo Choi*
Department of Infectious Diseases, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea
Correspondence to: Tel: +82-2-2049-6055; Fax: +82-2-3436-5880; E-mail: ischoi@konkuk.ac.kr
Received: September 21, 2017; Revised: November 26, 2017; Accepted: December 26, 2017; Published online: December 28, 2017.
The zoonotic transmission of hepatitis E virus (HEV) is mostly mediated by HEV-3 and HEV-4, and domestic pigs are an important reservoir for these genotypes. A survey of 14 pig farms in Korea revealed HEV RNA in 30 of 148 (20.3%) fecal samples. HEV-3a and HEV-4c subtypes were identified from five (36%) and two (14%) pig farms, respectively. Phylogenetic analysis indicated that the isolated HEV strains were closely related with previously reported zoonotic strains in Korea. This genetic analysis can partially explain the possible source of the zoonotic transmission of HEV to humans in Korea.
Keywords: HEV-3, HEV-4, pig, feces, zoonosis

© 2017 The Korean Society of Veterinary Science.