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J Vet Sci 2018; 19(1): 137-143  https://doi.org/10.4142/jvs.2018.19.1.137
Magnetic resonance imaging characteristics of ischemic brain infarction over time in a canine stroke model
Sooyoung Choi1,†, Daji Noh2, Youngwhan Kim3, Inseong Jeong3, Hojung Choi4, Youngwon Lee4, Kija Lee2,*
1Ian Animal Diagnostic Center, Seoul 06014, Korea
2College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea
3Royal Animal Medical Center, Seoul 02117, Korea
4College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea
Correspondence to: Kija Lee
Tel: +82-53-950-5961; Fax: +82-53-950-5955; E-mail: leekj@knu.ac.kr
Present address: College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea
Received: October 31, 2016; Revised: February 22, 2017; Accepted: March 26, 2017; Published online: January 31, 2018.
Abstract
This study describes magnetic resonance imaging (MRI) results and changes in lateral ventricular size over time in a canine ischemic stroke model. T1- and T2-weighted (T1W, T2W) imaging and fluid-attenuated inversion recovery (FLAIR) sequence MRI were performed at 3 h and 3, 8, and 35 days after brain infarct induction. Diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping were performed at 8 and 35 days. A total of 29 brain lesions were induced successfully in 12 of 14 beagle dogs. At 3 h, T2W and FLAIR detected hyperintense lesions in three randomly selected dogs. On T1W, all lesions appeared hypointense to isointense at 3 h, isointense (18/29) or hypointense (11/29) at 3 days, hypointense to isointense with peripheral hyperintensity (24/26) at 8 days, and hypointense (18/26) at 35 days. Infarcts on DWI/ADC were hypointense to isointense centrally, with the periphery hyperintense/hyperintense (17/26) at 8 days and hypointense/hyperintense (19/26) at 35 days. A marked increase in lateral ventricular size was observed in dogs with cerebral infarcts. In conclusion, T2W and FLAIR were useful for detecting early stage (3 h to 3 days) brain infarction. T1W and DWI were useful for detecting neuronal necrosis and providing supplemental information for phase evaluation.
Keywords: brain infarction, dogs, lateral ventricles, magnetic resonance imaging, time passage


© 2018 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.