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J Vet Sci 2018; 19(1): 157-160  https://doi.org/10.4142/jvs.2018.19.1.157
Prepubertal growth and single nucleotide polymorphism analysis of the growth hormone gene of low birth weight Holstein calves
Younghye Ro1, Woojae Choi1, Hoyung Kim2, Hojin Jang3, Hoseon Lee4, Yoonseok Lee5,*, Danil Kim1,6,*
1Department of Farm Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
2University Animal Farm, College of Agriculture & Life Sciences, 6Farm Animal Clinical Training and Research Center, Institute of Green-Bio Science and Technology, Seoul National University, Pyeongchang 25354, Korea
3Dairy Cattle Improvement Center, National Agricultural Cooperative Federation, Goyang 10292, Korea
4Hyun-ri Animal Clinic, Gapyeong 12437, Korea
5Department of Biotechnology and Genomic Informatics Center, College of Agriculture & Life Science, Hankyong National University, Anseong 17579, Korea
Correspondence to: Danil Kim, Yoonseok Lee
Tel: +82-33-339-6102; Fax: +82-33-339-6199; E-mails: danilkim@snu.ac.kr (D Kim), yoonseok95@hknu.ac.kr (Y Lee)
Received: December 26, 2016; Revised: May 3, 2017; Accepted: June 8, 2017; Published online: January 31, 2018.
Holstein calves weighing less than 20 kg at birth have been noted in Korea. Due to insufficient information, we raised small calves with age-matched normal birth weight Holstein calves and determined body weights before puberty. In addition, 3 single nucleotide polymorphisms (SNPs) of the growth hormone (GH) gene were analyzed. Up to 10 months of age, low birth weight calves were smaller than normal weight calves. In exon 5 of the GH gene, SNP genotype variation was detected in some small calves; however, this did not appear to be the only factor inducing low birth weight and slow growth.
Keywords: Holstein calf, growth hormone, low birth weight, prepubertal growth, single nucleotide polymorphism

© 2018 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.