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J Vet Sci 2018; 19(2): 162-171  https://doi.org/10.4142/jvs.2018.19.2.162
Comparative aspects of microRNA expression in canine and human cancers
Kabiru Sahabi1, Gayathri T. Selvarajah1,*, Rasedee Abdullah2, Yoke Kqueen Cheah3, Geok Chin Tan4
Departments of 1Veterinary Clinical Studies and 2Veterinary Laboratory Diagnostics, Faculty of Veterinary Medicine, and 3Department of Biomedical Sciences, Faculty of Medicine and Biomedical Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
4Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia
Correspondence to: Tel: +603-8609-3922; Fax: +603-8947-1971; E-mail: gayathri@upm.edu.my
Received: February 7, 2017; Revised: May 19, 2017; Accepted: July 14, 2017; Published online: March 31, 2018.
Abstract
MicroRNAs (miRNAs) have important roles in all biological pathways in multicellular organisms. Over 1,400 human miRNAs have been identified, and many are conserved among vertebrates and invertebrates. Regulation of miRNA is the most common mode of post-transcriptional gene regulation. The miRNAs that are involved in the initiation and progression of cancers are termed oncomiRs and several of them have been identified in canine and human cancers. Similarly, several miRNAs have been reported to be down-regulated in cancers of the two species. In this review, current information on the expression and roles of miRNAs in oncogenesis and progression of human and canine cancers, as well the roles miRNAs have in cancer stem cell biology, are highlighted. The potential for the use of miRNAs as therapeutic targets in personalized cancer therapy in domestic dogs and their possible application in human cancer counterparts are also discussed.
Keywords: dogs, gene expression, microRNAs, neoplasms, stem cells


© 2018 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.