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Kilovoltage radiotherapy for companion animals: dosimetric comparison of 300 kV, 450 kV, and 6 MV X-ray beams
Jaehyeon Seo1, Jaeman Son1, Yeona Cho2, Nohwon Park3, Dong Wook Kim4, Jinsung Kim2,*, Myonggeun Yoon1,*
1Department of Bio-Convergence Engineering, Korea University, Seoul, Korea
2Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
3Korea Animal Cancer Center, 456 Nowon-ro, Nowon-gu, Seoul 01684, Korea
4Department of Radiation Oncology, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea
Correspondence to: Tel: +82-2-3290-5651; Fax: +82-2-940-2829; E-mails: radioyoon@korea.ac.kr (M Yoon), jinsung.k@gmail.com (J Kim)
Received: December 14, 2017; Revised: March 21, 2018; Accepted: March 31, 2018; Published online: April 12, 2018.
Radiotherapy for the treatment of cancer in companion animals is currently administered using megavoltage X-ray machines. Because these machines are expensive, most animal hospitals do not perform radiotherapy. This study evaluated the ability of relatively inexpensive kilovoltage X-ray machines to treat companion animals. A simulation study based on a treatment planning system was performed for tumors of the brain (non-infectious meningoencephalitis), nasal cavity (malignant nasal tumors), forefoot (malignant muscular tumors), and abdomen (malignant intestinal tumors). The results of kilovoltage (300 kV and 450 kV) and megavoltage (6 MV) X-ray beams were compared. Whereas 300 kV and 6 MV X-ray beams provided optimal radiation dose homogeneity and conformity, respectively, for brain tumors, 6 MV X-rays provided optimal homogeneity and radiation conformity for nasal cavity, forefoot and abdominal tumors. Although megavoltage X-ray beams provided better radiation dose distribution in most treated animals, the differences between megavoltage and kilovoltage X-ray beams were relatively small. The similar therapeutic effects of kilovoltage and 6 MV X-ray beams suggest that kilovoltage X-ray beams may be effective alternatives to megavoltage X-ray beams in treating cancers in companion animals.
Keywords: kilovoltage X-ray, radiotherapy, homogeneity, conformity

© 2018 The Korean Society of Veterinary Science.