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Oxidative stress and hepatic injury induced in mice fed with Sarcocystis hirsuta cyst extract
Maryam Sasani1, Reza Nabavi1,*, Mohammad Reza Hajinezhad 2, Parisa Hasanein3
1Department of Pathobiology, Faculty of Veterinary Medicine, University of Zabol, Zabol 98613635856, Iran
2Department of Basic Veterinary Science, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
3Department of Biology, School of Basic Sciences, University of Zabol, Zabol, Iran
Correspondence to: Tel: +98-5431232250; Fax: +98-5431232250; E-mail: mhajinezhad@yahoo.com
Received: January 8, 2018; Revised: February 24, 2018; Accepted: March 15, 2018; Published online: April 12, 2018.
Abstract
We studies toxic effects of Sarcocystis hirsuta cyst extract in mice. Degenerative changes were found in the mice received fresh, frozen and heated S. hirsuta cyst extract. There were increases in the levels of serum aspartate aminotransferase and alanine aminotransferase (AST and ALT) as well as hepatic and brain malondialdehyde (MDA) levels with a concomitant decrease in catalase (CAT) and superoxide dismutase (SOD) activities of mice received fresh and frozen S. hirsuta extracts. Gavage feeding of heated S. hirsuta cyst extract had no effects on liver enzymes and brain MDA content, but increased liver MDA. Mice in this group showed reduced CAT and SOD activities as well as increased hepatic MDA compared to control group. These findings indicate that the extract of S. hirsuta cyst can induce oxidative stress and hepatic injury even after heating.
Keywords: Sarcocystis hirsuta, mice, aspartate aminotransferase, alanine aminotransferase, malondialdehyde


© 2018 The Korean Society of Veterinary Science.