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Pharmacokinetics of enrofloxacin HCl-2H2O (ENRO-C) in dogs and PK/PD Monte Carlo simulations against Leptospira sp.
Hector Sumano1, Luis Ocampo1, Graciela Tapia2, C de Jesus Mendoza1, Lilia Gutierrez1,*
1Department of Physiology and Pharmacology, National Autonomous Uni¬versity of Mexico (UNAM), Mexico City, Mexico 04510
2Department of Genetics and Biostatistics. National Autonomous Uni¬versity of Mexico (UNAM), Mexico City, Mexico 04510
Correspondence to: Tel: +52-55-56-22-59-80 ext 104 and 108; Fax: +52-55-56-22-59-08 ext 102; E-mail: liliago@unam.mx
Received: January 17, 2018; Revised: February 24, 2018; Accepted: March 20, 2018; Published online: April 12, 2018.
Abstract
Pharmacokinetics/pharmacodynamics (PK/PD) ratios of reference enrofloxacin (Enro-R) and enrofloxacin as HCl-2H2O (Enro-C), as well as Monte Carlo simulations based on composite MIC50 and MIC90 vs. Leptospira sp., were carried out in dogs after their IM and oral administration (10 mg/kg). Plasma determination of enrofloxacin was achieved by means of high performance liquid chromatography (HPLC). Maximum plasma concentration values after oral administration were 1.47 ± 0.19 µg/mL and 5.3 ± 0.84 µg/mL for Enro-R and Enro-C, respectively, and 1.6 ± 0.12 µg/mL and 7.6 ± 0.93 µg/mL after IM administration. Area under the plasma vs. time concentrations in 24 h (AUC0-24) were 8.02 µg/mL/h and 36.2 µg/mL/h for Enro-Roral and Enro-Coral, respectively, and 8.55 ± 0.85 µg/mL/h and 56.4 ± 6.21 µg/mL/h after IM administration of these drugs. Only PK/PD ratios and Monte Carlo simulations obtained with Enro-C, anticipate that its IM administration to dogs will result in therapeutic concentrations to treat leptospirosis. This is the first time enrofloxacin has been recommended to treat this disease in dogs.
Keywords: enrofloxacin hydrochloride-dihydrate, dogs, PK/PD, leptospirosis, Pharmacokinetic


© 2018 The Korean Society of Veterinary Science.