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Isolation and characterization of a Korean porcine deltacoronavirus strain KNU16-07
Guehwan Jang1,†, Seong-Hee Kim2,†, Yoo Jin Lee1, Seungjoon Kim3, Du Sik Lee4, Kyoung-Ki Lee2,*, Changhee Lee1,*
1Animal Virology Laboratory, School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Korea
2Animal Disease Diagnostic Division, Animal and Plant Quarantine Agency, Gimcheon, 39660, Korea
3College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea
4College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea
Correspondence to: Tel: +82-53-950-7365; Fax: +82-53-955-5522; E-mail: changhee@knu.ac.kr (C Lee), naturelkk@korea.kr (KK Lee)
The first two authors contributed equally to this work.
Received: March 30, 2018; Revised: April 13, 2018; Accepted: April 23, 2018; Published online: April 26, 2018.
Abstract
Porcine deltacoronavirus (PDCoV) has emerged in several pig-raising countries and has also been a causative pathogen associated with diarrheal diseases in South Korea since 2014. In the present study, we were able to isolate and cultivate one Korean PDCoV strain in cell culture and further investigated its pathogenicity. PDCoV-inoculated piglets showed watery diarrhea accompanied by acute enteritis in the natural host. Sequencing analysis demonstrated genetic stability of KNU16-07 for at least thirty serial passages.
Keywords: Porcine deltacoronavirus; Cell culture isolation; Pathogenicity; Genome analysis


© 2018 The Korean Society of Veterinary Science.