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J Vet Sci 2018; 19(3): 319-330  https://doi.org/10.4142/jvs.2018.19.3.319
Microglial involvement in the development of olfactory dysfunction
Yoojin Seo1,†, Hyung-Sik Kim1,†, Kyung-Sun Kang2,3,*
1Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan 49241, Korea
2Adult Stem Cell Research Center, and 3Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea
Correspondence to: Tel: +82-2-880-1246; Fax: +82-2-876-7610; E-mail: kangpub@snu.ac.kr
The first two authors contributed equally to this work.
Received: March 6, 2017; Revised: September 20, 2017; Accepted: October 7, 2017; Published online: May 31, 2018.
Abstract
Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment as an early marker in the diagnosis of neurological disorders. In this review, we describe the nature of olfactory dysfunction and the advantage of using animal models in olfaction study, and we include a brief introduction to olfactory behavior tests widely used in this field. The contribution of microglia in the neurodegenerative processes including olfactory impairment is then discussed to provide a comprehensive description of the physiopathological role of interactions between neurons and microglia within the olfactory system.
Keywords: Niemann-Pick disease type C, microglia, neurodegenerative diseases, smell


© 2018 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.