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J Vet Sci 2018; 19(3): 472-476  https://doi.org/10.4142/jvs.2018.19.3.472
Double filtration plasmapheresis in the treatment of hyperproteinemia in dogs affected by Leishmania infantum
Francesca Perondi1,*, Claudio Brovida2, Gianila Ceccherini1, Grazia Guidi1, Ilaria Lippi1
1Department of Veterinary Sciences, University of Pisa, 56122 Pisa, Italy
2ANUBI Companion Animal Hospital, 10024 Moncalieri, Italy
Correspondence to: Tel: +39-50-2210100; Fax: +39-50-2210654; E-mail: f.perondi87@gmail.com
Received: August 1, 2017; Revised: October 23, 2017; Accepted: November 24, 2017; Published online: May 31, 2018.
Abstract
Three dogs were evaluated for severe hyperproteinemia and hyperglobulinemia secondary to Leishmania infantum. Double filtration plasmapheresis (DFPP) was performed in two dogs at days 1, 2, and 6 after presentation. The third dog received DFPP at days 1 and 3 after presentation and eleven hemodialysis treatments. Significant reduction in serum total protein (p < 0.0001), alpha-1 (p = 0.023), alpha-2 (p = 0.018), gamma globulins (p = 0.0105), and a significant increase in albumin/globulin ratio (p = 0.0018) were found. DFPP may be a promising therapeutic technique for rapid resolution of signs of hyperproteinemia in dogs affected by L. infantum.
Keywords: Leishmania infantum, dogs, double filtration plasmapheresis, hyperproteinemia


© 2018 The Korean Society of Veterinary Science.

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