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J Vet Sci 2018; 19(3): 472-476  https://doi.org/10.4142/jvs.2018.19.3.472
Double filtration plasmapheresis in the treatment of hyperproteinemia in dogs affected by Leishmania infantum
Francesca Perondi1,*, Claudio Brovida2, Gianila Ceccherini1, Grazia Guidi1, Ilaria Lippi1
1Department of Veterinary Sciences, University of Pisa, 56122 Pisa, Italy
2ANUBI Companion Animal Hospital, 10024 Moncalieri, Italy
Correspondence to: Tel: +39-50-2210100; Fax: +39-50-2210654; E-mail: f.perondi87@gmail.com
Received: August 1, 2017; Revised: October 23, 2017; Accepted: November 24, 2017; Published online: May 31, 2018.
Three dogs were evaluated for severe hyperproteinemia and hyperglobulinemia secondary to Leishmania infantum. Double filtration plasmapheresis (DFPP) was performed in two dogs at days 1, 2, and 6 after presentation. The third dog received DFPP at days 1 and 3 after presentation and eleven hemodialysis treatments. Significant reduction in serum total protein (p < 0.0001), alpha-1 (p = 0.023), alpha-2 (p = 0.018), gamma globulins (p = 0.0105), and a significant increase in albumin/globulin ratio (p = 0.0018) were found. DFPP may be a promising therapeutic technique for rapid resolution of signs of hyperproteinemia in dogs affected by L. infantum.
Keywords: Leishmania infantum, dogs, double filtration plasmapheresis, hyperproteinemia

© 2018 The Korean Society of Veterinary Science.

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