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Bee venom stimulation into lung meridian acupoint reduces inflammation in a mouse model of carrageenan-induced pleurisy: an alternative therapeutic approach for the respiratory inflammatory disease
Hoon-Seong Choi1, Suk-Yun Kang2, Dae-Hyun Roh3, Sheu-Ran Choi1, Yeonhee Ryu2,*, Jang-Hern Lee1,*
1Department of Veterinary Physiology, BK21 PLUS Program for Creative Veterinary Science Research, Research Institute for Veterinary Science and College of Veterinary Medicine, Seoul National University, Seoul, Korea
2KM Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon, Korea
3Department of Oral Physiology, School of Dentistry, Kyung Hee University, Seoul, Korea
Correspondence to: Tel +82-2-880-1272; Fax +82-2-885-2732; E-mails: yhryu@kiom.re.kr (Y Ryu), jhl1101@snu.ac.kr (JH Lee)
Received: February 21, 2018; Revised: May 30, 2018; Accepted: June 4, 2018; Published online: June 21, 2018.
Abstract
Respiratory inflammation is frequent and fatal pathologic state encountered in veterinary medicine. Although diluted bee venom (dBV) has potent anti-inflammatory effects, the clinical use of dBV is limited to several chronic inflammatory diseases. The present study was designed to propose the acupoint treatment of dBV as a novel therapeutic strategy for respiratory inflammatory disease. Experimental pleurisy was induced by injection of carrageenan into left pleural space in mouse. dBV was injected into a specific lung meridian acupoint (LU-5) or into arbitrary non-acupoint located near the midline of the back in mouse. The inflammatory responses were evaluated by analysis the inflammatory indicators in pleural exudate. dBV injection into LU-5 acupoint significantly suppressed the increase of pleural exudate volume, leukocyte accumulation, MPO activity. Moreover, dBV acupoint treatment effectively inhibited the production of IL-1β, but not TNF-α in pleural exudate. On the other hand, dBV treatment on non-acupoint did not inhibit the inflammatory responses in carrageenan-induced pleurisy. The present results demonstrate that dBV stimulation into the LU-5 lung meridian acupoint produces significant anti-inflammatory effects on carrageenan-induced pleurisy suggesting that dBV acupuncture as a promising alternative medicine therapy for respiratory inflammatory diseases.
Keywords: Bee venom, Acupuncture, Carrageenan-induced pleurisy, Anti-inflammation


© 2018 The Korean Society of Veterinary Science.