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J Vet Sci 2018; 19(4): 500-504  https://doi.org/10.4142/jvs.2018.19.4.500
Oxidative stress and hepatic injury induced in mice fed a Sarcocystis hirsuta cyst extract
Maryam Sasani1, Reza Nabavi1,*, Mohammadreza Hajinezhad2, Parisa Hasanein3
Departments of 1Pathobiology and 2Basic Veterinary Science, Faculty of Veterinary Medicine, and 3Department of Biology, School of Basic Sciences, University of Zabol, Zabol 98613635856, Iran
Correspondence to: Tel: +98-5431232250; Fax: +98-5431232251; E-mail: nabavir796@gmail.com
Received: January 8, 2018; Revised: February 24, 2018; Accepted: March 15, 2018; Published online: July 31, 2018.
We studied the toxic effects of a Sarcocystis hirsuta cyst extract fed to mice. Degenerative changes were found in mice gavage-fed fresh, frozen, and heat-treated S. hirsuta cyst extract. There were increases in the levels of serum aspartate aminotransferase and alanine aminotransferase as well as hepatic and brain malondialdehyde (MDA) levels along with concomitant decreases in catalase (CAT) and superoxide dismutase (SOD) activities of mice receiving fresh and frozen S. hirsuta extracts. Gavage feeding of heat-treated S. hirsuta cyst extract had no effects on liver enzymes or brain MDA content, but the liver MDA level did increase. Mice in the heat-treated cyst group showed reduced CAT and SOD activities as well as increased hepatic MDA levels compared to those in the control group. These results indicate that an extract of S. hirsuta cyst can induce oxidative stress and hepatic injury, even after heat treatment.
Keywords: Sarcocystis hirsuta, alanine aminotransferase, aspartate aminotransferases, malondialdehyde, mice 

© 2018 The Korean Society of Veterinary Science.

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