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J Vet Sci 2018; 19(4): 550-556  https://doi.org/10.4142/jvs.2018.19.4.550
Kilovoltage radiotherapy for companion animals: dosimetric comparison of 300 kV, 450 kV, and 6 MV X-ray beams
Jaehyeon Seo1, Jaeman Son1, Yeona Cho2, Nohwon Park3, Dong Wook Kim4, Jinsung Kim2,*, Myonggeun Yoon1,*
1Department of Bio-Convergence Engineering, Korea University, Seoul 02841, Korea
2Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul 03722, Korea
3Korea Animal Cancer Center, Seoul 01684, Korea
4Department of Radiation Oncology, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea
Correspondence to: Tel: +82-2-3290-5651; Fax: +82-2-940-2829; E-mails: radioyoon@korea.ac.kr (M Yoon), jinsung.k@gmail.com (J Kim)
Received: December 14, 2017; Revised: March 21, 2018; Accepted: March 31, 2018; Published online: July 31, 2018.
Radiotherapy for the treatment of cancer in companion animals is currently administered by using megavoltage X-ray machines. Because these machines are expensive, most animal hospitals do not perform radiotherapy. This study evaluated the ability of relatively inexpensive kilovoltage X-ray machines to treat companion animals. A simulation study based on a commercial treatment-planning system was performed for tumors of the brain (non-infectious meningoencephalitis), nasal cavity (malignant nasal tumors), forefoot (malignant muscular tumors), and abdomen (malignant intestinal tumors). The results of kilovoltage (300 kV and 450 kV) and megavoltage (6 MV) X-ray beams were compared. Whereas the 300 kV and 6 MV X-ray beams provided optimal radiation dose homogeneity and conformity, respectively, for brain tumors, the 6 MV X-rays provided optimal homogeneity and radiation conformity for nasal cavity, forefoot, and abdominal tumors. Although megavoltage X-ray beams provided better radiation dose distribution in most treated animals, the differences between megavoltage and kilovoltage X-ray beams were relatively small. The similar therapeutic effects of the kilovoltage and 6 MV X-ray beams suggest that kilovoltage X-ray beams may be effective alternatives to megavoltage X-ray beams in treating cancers in companion animals.
Keywords: X-ray, companion animals, radiation therapy

© 2018 The Korean Society of Veterinary Science.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.